Opportunity Information: Apply for CDC RFA GH 23 0016
This funding opportunity, CDC RFA GH 23 0016, is a PEPFAR-supported cooperative agreement from the Centers for Disease Control and Prevention (HHS/CDC, Center for Global Health) focused on strengthening laboratory systems that underpin HIV and TB programs while also supporting broader multi-disease readiness. The main idea is to move away from laboratory services that operate in isolated silos and instead build more integrated, responsive, and quality-assured diagnostic networks that can meet day-to-day program needs and also pivot during outbreaks and pandemics. The opportunity emphasizes that modern public health demands reliable laboratory capacity across the full testing continuum, from point-of-care testing sites to national reference laboratories, and that the growth of multi-pathogen platforms makes coordinated systems and smart testing algorithms even more important.
The total anticipated funding for Year 1 is approximately USD 30,000,000, contingent on the availability of funds. The notice lists an "award ceiling" of 0 for Year 1, which is a formatting quirk that sometimes appears in federal postings and generally should not be interpreted as no money being available; the narrative and total funding figure make clear that CDC expects to fund work up to the stated level across awards. CDC expects to make 1 to 4 awards, with the exact award amounts and the geographic scope finalized at the time of award. Applicants are asked to design proposals that could collectively spend up to USD 30,000,000 to carry out activities aligned with PEPFAR/CDC laboratory systems strengthening priorities.
Eligibility is broadly open (unrestricted), meaning any type of organization can apply as long as it meets any additional eligibility clarifications described in the full announcement. The funding instrument is a cooperative agreement, which typically means substantial involvement from CDC during implementation, such as joint planning, technical consultation, coordination with country and regional partners, and alignment with PEPFAR program strategy. The activity category is health (CFDA 93.067). The notice was created February 3, 2023, with an original application due date of April 4, 2023, by 11:59 pm Eastern Time for electronic submissions.
A key feature of this NOFO is geographic flexibility paired with an expectation of transferability. Applicants can choose the region or regions they want to focus on, including Africa, Asia, and/or the Western Hemisphere. At the same time, proposals are expected to include activities and approaches that could be applied globally or adapted for other geographies. In practice, that means CDC is looking for work that is not only tailored to the needs of selected countries or regions, but also produces tools, models, implementation approaches, and quality improvement methods that can be reused elsewhere within PEPFAR-supported laboratory networks.
The technical scope centers on building and sustaining efficient, effective laboratory systems that support prevention, detection, and treatment for HIV, TB, and other HIV-related diseases and conditions. The announcement highlights how recent outbreaks and pandemics exposed weaknesses in fragmented systems and reinforced the need for accurate and responsive tiered diagnostic networks. "Tiered" networks generally refer to connected layers of testing capacity (for example, community and clinic-based testing, district or provincial laboratories, national reference laboratories, and regional specialized centers), with defined referral pathways, specimen transport systems, data flows, and quality oversight. Strengthening these networks helps ensure that patients get timely results and that programs have the data needed to monitor performance, quality, and coverage.
Several priority activity areas stand out. One is partnerships and capacity building for the timely evaluation, validation, and implementation of new diagnostics, including both in-house assays and commercial products. This includes the practical work required to responsibly introduce new tests into routine use: analytic and clinical verification, evaluation of performance in local contexts, development or refinement of testing algorithms (including multi-pathogen or reflex testing approaches), and ensuring that staff are trained and systems are ready for deployment. Another major area is the expansion and support of regional, national, and sub-national programs that build laboratory capacity, which can include workforce development, equipment and instrument integration planning, standard operating procedures, quality management systems, biosafety practices, and strengthening the linkages between clinics and laboratories so results flow back quickly to providers and patients.
Continuous quality improvement (CQI) is emphasized as a core theme across the laboratory system, including point-of-care (POC) testing sites. POC testing can dramatically increase access and reduce turnaround time, but it also introduces challenges such as decentralized staffing, variable infrastructure, and the need for consistent external quality assessment and supervision. The NOFO signals interest in CQI programs and tools that can be scaled across networks, strengthening routine monitoring, corrective action, proficiency testing participation, supervisory systems, and the clinic-laboratory interface. The clinic-laboratory interface component points to reducing delays and errors that occur between ordering, specimen collection, transport, testing, results reporting, and clinical action, where many real-world failures happen.
The announcement also underscores multi-disease public health diagnostic networks and laboratory data management as important elements, reflecting the reality that countries increasingly rely on shared platforms, shared supply chains, and shared data systems to respond to multiple diseases efficiently. While HIV and TB remain central, the stated direction supports a broader diagnostic ecosystem that can contribute to pandemic preparedness and response. Laboratory data management in this context typically includes strengthening the flow and use of laboratory information, whether through laboratory information systems, data interoperability, standardized indicators, and improving data quality and timeliness so decision-makers can track testing volumes, positivity rates, turnaround times, quality events, instrument uptime, reagent stock status, and network performance.
Overall, this NOFO is looking for one to a few strong implementers that can operate at global and regional levels, help countries modernize and integrate their diagnostic networks, introduce new diagnostic technologies responsibly, and institutionalize continuous quality improvement from POC sites through reference laboratories. The intended result is laboratory systems that are dependable for routine HIV and TB service delivery, adaptable for new diagnostic needs, and better prepared to support public health responses to emerging threats.Apply for CDC RFA GH 23 0016
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Supporting Continuous Quality Improvement, Partnerships, and Innovation for Sustained and Responsive Laboratory Systems, Tiered Diagnostic Networks, and Laboratory Data Management under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Feb 03, 2023.
- Applicants must submit their applications by Apr 04, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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