Opportunity Information: Apply for PAR 23 235
The National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional) funding opportunity (PAR-23-235) is an NIH discretionary grant aimed at supporting Biomedical Technology Resource Centers (BTRCs). These centers are intended to function as national hubs that design, develop, and refine cutting-edge biomedical imaging and bioengineering technologies, with the technology agenda being driven by real needs identified by basic science, translational, and clinical research communities. In practice, the core idea is not just to fund a single lab's research, but to build and sustain a shared national resource that creates impactful tools and methods and then actively makes them usable by a broad set of outside investigators.
A defining feature of a BTRC under this FOA is the expectation that the center will both innovate and serve. On the innovation side, the BTRC conducts research and development to produce new or improved technologies, which can include hardware, software, methods, workflows, or integrated platforms relevant to biomedical imaging and bioengineering. On the service side, the center is expected to provide access to these technologies for other researchers, meaning the BTRC should be set up to support external users who want to apply the tools to their own scientific questions. In addition, the FOA emphasizes training and dissemination as core responsibilities: BTRCs are expected to train members of the broader research community in how to use the technologies properly and effectively, and to disseminate the technologies widely so they can be adopted beyond the host institution. The overall intent is to accelerate biomedical discovery by reducing barriers to advanced technology, standardizing best practices, and spreading specialized expertise.
The activity uses the P41 mechanism, with clinical trials listed as optional, which typically signals that applicants may propose work that includes a clinical trial if it fits the center's technology development and validation goals, but a clinical trial is not required. The funding instrument type is a grant and the activity category is health (CFDA 93.286), consistent with NIH support for biomedical research infrastructure and enabling technologies. While the notice provides an original closing date of 2026-09-07, applicants would still need to follow NIH submission rules, including any relevant receipt dates, application instructions, and policy requirements linked to this FOA.
Eligibility is broad and spans many types of U.S.-based organizations. Eligible applicants include state, county, city, township, and special district governments; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education when specified in the listing); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and Indian/Native American Tribal Governments other than federally recognized tribes.
At the same time, the FOA draws clear lines around foreign involvement. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed. Practically, that means the applicant organization must be domestic and eligible, but certain defined foreign collaborations or elements may be permissible if they meet NIH policy and are appropriately justified in the application.
In summary, this opportunity is designed for applicants that can operate a national-scale technology resource center: one that develops new biomedical imaging and bioengineering technologies, provides those capabilities to a broader user community, trains researchers in their use, and actively disseminates the resulting tools and know-how. The program is structured to build shared infrastructure and expertise that can multiply the impact of technology development across many independent research projects, rather than limiting the benefits to a single team or institution.Apply for PAR 23 235
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286.
- This funding opportunity was created on 2023-07-28.
- Applicants must submit their applications by 2026-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional) - PAR-23-235
What is this funding opportunity?
This opportunity (PAR-23-235) is an NIH discretionary grant that supports National Centers for Biomedical Imaging and Bioengineering (NCBIB) through the P41 mechanism. It is intended to fund Biomedical Technology Resource Centers (BTRCs) that operate as national hubs for developing and sharing advanced biomedical imaging and bioengineering technologies.
What is the main goal of a Biomedical Technology Resource Center (BTRC) under this FOA?
The goal is to build and sustain a shared national resource that creates impactful imaging and bioengineering tools and methods, and then actively makes them usable by a broad community of outside investigators. The emphasis is not on supporting a single lab, but on creating a center that multiplies impact by serving many research groups.
What kinds of work is a BTRC expected to do?
A BTRC is expected to both innovate and serve. On the innovation side, it conducts research and development to design, develop, and refine cutting-edge biomedical imaging and bioengineering technologies. On the service side, it provides access and support so external researchers can use those technologies for their own scientific questions.
What types of technologies can be developed or improved through this program?
The FOA indicates technologies may include hardware, software, methods, workflows, or integrated platforms that are relevant to biomedical imaging and bioengineering.
Who is supposed to drive the technology agenda for the center?
The technology agenda is expected to be driven by real needs identified by basic science, translational, and clinical research communities. In other words, the center is expected to build tools that researchers actually need, not just tools that are interesting to develop in isolation.
Is this funding meant to support only the applicant organization’s internal research?
No. A defining expectation is that the center functions as a shared national resource. It should be set up to support outside investigators by providing access to the technologies and helping external users apply them to their own projects.
What does “service” mean in the context of a BTRC?
Service means providing access to the technologies the center develops and supporting external users who want to apply those technologies. The center should have the capability and structure to assist other researchers beyond the host institution.
Are training and dissemination required components?
Yes. Training and dissemination are emphasized as core responsibilities. BTRCs are expected to train members of the broader research community to use the technologies properly and effectively, and to disseminate the technologies widely so they can be adopted beyond the host institution.
Why does the FOA emphasize training and dissemination?
The stated intent is to accelerate biomedical discovery by reducing barriers to advanced technology, standardizing best practices, and spreading specialized expertise so that more investigators can effectively use advanced imaging and bioengineering capabilities.
What grant mechanism is used for this program?
The activity uses the NIH P41 mechanism.
Are clinical trials required?
No. Clinical trials are listed as optional. This generally means an applicant may propose work that includes a clinical trial if it fits the center’s technology development and validation goals, but a clinical trial is not required.
What is the funding instrument type and category?
The funding instrument type is a grant. The activity category is health, and it is associated with CFDA 93.286.
What is the closing date mentioned for this opportunity?
The notice provides an original closing date of 2026-09-07.
Do applicants still need to follow NIH submission rules and receipt dates?
Yes. Even though a closing date is listed, applicants are expected to follow NIH submission rules, including relevant receipt dates, application instructions, and policy requirements linked to the FOA.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations. Eligible applicants include various levels of government (state, county, city, township, special district), federally recognized Native American tribal governments, public housing authorities/Indian housing authorities, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations other than small businesses, and small businesses.
Are particular institution types specifically highlighted as eligible?
Yes. The FOA explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and Indian/Native American Tribal Governments other than federally recognized tribes.
Can non-U.S. (foreign) organizations apply as the applicant?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as applicant organizations under this FOA.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are any foreign collaborations allowed at all?
Yes. The FOA states that foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed. This means the applicant organization must be domestic and eligible, but certain defined foreign collaborations or elements may be permissible if they meet NIH policy and are appropriately justified.
What is the intended impact of funding these centers?
The program is intended to accelerate biomedical discovery by building shared infrastructure and expertise that reduces barriers to advanced technology, supports external investigators, improves standardization and best practices, and helps widely spread specialized tools and know-how.
What distinguishes this program from a typical research grant?
The distinguishing feature is the expectation to operate a national-scale resource center. The center must both create new or improved technology and actively serve a broader community through access, support, training, and dissemination, rather than focusing benefits mainly within a single research team.
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