Opportunity Information: Apply for PAS 21 245
The Limited Competition: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed) funding opportunity (PAS-21-245) is a discretionary NIH grant program under the U.S. Department of Health and Human Services that supports early-stage, short-term research projects aimed at building fundamental knowledge about how chemical threats affect the skin. The emphasis is on developing or strengthening the basic scientific foundation needed to understand skin injury and related biological responses caused by harmful chemical exposures. As an R34 mechanism, it is generally positioned as an exploratory or developmental award meant to help investigators generate key preliminary data, refine research approaches, or establish feasibility for future, larger-scale research efforts. Clinical trials are not allowed under this opportunity, meaning supported work should remain in the preclinical, mechanistic, foundational, or non-interventional human research space rather than testing interventions in clinical trial formats.
In terms of administrative details, this opportunity is offered as a grant (Funding Instrument Type: Grant) within the Health funding activity category and is associated with CFDA numbers 93.846 and 93.855. The program was created on June 14, 2021, and the original closing date is September 7, 2024. The expected number of awards is 8, and the award ceiling is $225,000, indicating a relatively modest budget scope consistent with focused, foundational projects rather than large, multi-year clinical studies or extensive field trials. Because it is labeled a limited competition, applicants should pay close attention to any eligibility or access restrictions described in the full announcement and related NIH guidance, since limited competitions often target a specific community, research network, or set of institutions, or require certain conditions to be met before applying.
Eligibility is broad and includes many types of domestic organizations and governmental entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; and public housing authorities/Indian housing authorities. Academic institutions are eligible as well, including public and state-controlled institutions of higher education and private institutions of higher education. Tribal entities may apply, including federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized tribal governments. The opportunity is also open to nonprofit organizations, both those with 501(c)(3) status and those without 501(c)(3) status (in both cases, other than institutions of higher education). For the private sector, eligibility includes for-profit organizations other than small businesses as well as small businesses. The listing also includes an "Others" category with a note to consult the announcement text for additional eligibility clarifications, which suggests there may be specific conditions or documentation requirements for certain applicant types.
Overall, the grant is designed for applicants proposing research that improves the scientific community's baseline understanding of chemical hazards to the skin, with the practical goal of strengthening the evidence base that can later inform prevention, diagnosis, and potential countermeasure development, while staying clearly outside the boundaries of clinical trial activity.Apply for PAS 21 245
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846, 93.855.
- This funding opportunity was created on Jun 14, 2021.
- Applicants must submit their applications by Sep 07, 2024. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: Limited Competition - Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed) (PAS-21-245)
What is this funding opportunity?
This is a discretionary NIH grant opportunity under the U.S. Department of Health and Human Services titled "Limited Competition: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed)" (PAS-21-245). It supports early-stage, short-term research projects focused on building foundational knowledge about how harmful chemical exposures affect the skin.
What is the main purpose of the program?
The purpose is to strengthen the basic scientific foundation needed to understand skin injury and related biological responses caused by chemical threats. The goal is fundamental understanding that can later support prevention, diagnosis, and eventual countermeasure development.
What does "Limited Competition" mean for applicants?
The opportunity is labeled a limited competition, which typically means there may be specific eligibility or access restrictions. Applicants should closely review the full announcement and related NIH guidance for any conditions that must be met before applying.
What grant mechanism is used?
The funding mechanism is an NIH R34, which is generally an exploratory or developmental award. It is commonly used to generate key preliminary data, refine research approaches, or establish feasibility for future, larger research efforts.
Are clinical trials allowed under this opportunity?
No. Clinical trials are not allowed. Supported work should stay in the preclinical, mechanistic, foundational, or non-interventional human research space and should not test interventions in a clinical trial format.
What types of research are a good fit?
Projects aimed at developing or strengthening a basic understanding of how chemical threats affect the skin, including mechanisms of injury and biological responses. The program emphasizes foundational science rather than intervention testing.
What types of research are not a good fit?
Research that qualifies as a clinical trial (for example, testing an intervention in a clinical trial format) is not allowable under this opportunity.
What is the funding instrument type?
The funding instrument type is a grant.
Which funding activity category does it fall under?
The opportunity is listed under the Health funding activity category.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.846 and 93.855.
When was the program created?
The program was created on June 14, 2021.
What is the original closing date?
The original closing date is September 7, 2024.
How many awards are expected?
The expected number of awards is 8.
What is the award ceiling?
The award ceiling is $225,000, which aligns with the program's focus on modest-scope, foundational projects rather than large, multi-year clinical studies or extensive field trials.
Who is eligible to apply?
Eligibility is broad and includes many domestic organization types and governmental entities, academic institutions, tribal entities, nonprofits, and for-profit organizations, including small businesses. Because this is a limited competition, applicants should still verify any additional conditions in the full announcement.
Are state governments eligible?
Yes. State governments are listed as eligible applicants.
Are local governments eligible (county, city, or township)?
Yes. County governments and city or township governments are listed as eligible applicants.
Are special district governments eligible?
Yes. Special district governments are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are listed as eligible applicants.
Are public housing authorities or Indian housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are universities and colleges eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are tribal governments eligible?
Yes. Federally recognized Native American tribal governments are listed as eligible applicants.
Are Native American tribal organizations that are not federally recognized eligible?
Yes. Native American tribal organizations (other than federally recognized tribal governments) are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with 501(c)(3) status (other than institutions of higher education) and nonprofit organizations without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible applicants, and small businesses are also listed as eligible applicants.
Is there an "Other" eligibility category?
Yes. The listing includes an "Others" category with a note to consult the announcement text for additional eligibility clarifications, which may include specific conditions or documentation requirements for certain applicant types.
How should applicants think about project scope and budget fit?
The award ceiling of $225,000 and the R34 mechanism suggest a focused, early-stage scope intended to support foundational research and feasibility work rather than large-scale, multi-year efforts.
What is the practical long-term impact this program is aiming for?
By improving the baseline scientific understanding of chemical hazards to the skin, the program aims to strengthen the evidence base that can later inform prevention, diagnosis, and potential countermeasure development.
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