Opportunity Information: Apply for RFA AG 24 019
This National Institutes of Health (NIH) funding opportunity, RFA-AG-24-019, supports R01 research projects that use comparative approaches across humans and nonhuman primates to understand why different primate species have different life spans, life histories, and aging-related outcomes. The central idea is that primates vary widely in longevity and patterns of aging, and those natural differences can be used as a kind of biological experiment to pinpoint mechanisms that may shape life span (how long a species tends to live) and health span (how long individuals remain relatively healthy and functional). A major emphasis is on identifying factors that vary across species and could help explain why humans generally live longer than many other primates, although the scope is not limited to that question alone.
The FOA invites studies that generate new data or make strong use of existing resources. Applicants can propose primary in vivo or in vitro work (for example, biological measurements collected directly from organisms or cells) as well as analyses of existing datasets and/or previously collected biospecimens. In practice, that means a project could involve new laboratory assays, comparative molecular or physiological profiling, or careful re-analysis of archived samples and longitudinal records from primate research colonies, field studies, or human cohorts, as long as the comparative design is clearly aimed at understanding cross-species differences tied to aging, longevity, and related life-history traits.
Because the opportunity is framed around “prospects for translation,” the NIH is looking for proposals that do more than just describe species differences. The expectation is that applicants will connect comparative findings to hypotheses about mechanisms that could eventually inform human aging biology and interventions. Translation here does not necessarily mean immediate clinical application; it can also mean identifying conserved pathways, protective adaptations, or modifiable risk factors suggested by primate comparisons that merit follow-up in human studies or preclinical models.
This is an R01 mechanism, which typically supports substantial, multi-year research programs with well-developed aims, rigorous methods, and strong analytical plans. The announcement explicitly states “Clinical Trial Not Allowed,” which generally means the proposed research should not include prospective assignment of human participants to interventions to evaluate health outcomes as a clinical trial. Applicants can still use human data, biospecimens, and observational designs, but they need to stay within the NIH definition boundaries that separate mechanistic or observational studies from clinical trials.
Eligibility is broad and includes many types of domestic and international organizations. Eligible applicants include state, county, and local governments; special districts; independent school districts; public and state-controlled universities; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); and other categories. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-U.S. entities (foreign organizations), and U.S. territories or possessions. This broad eligibility is intended to encourage diverse institutional participation and to leverage unique primate, human, and biobank resources that may be distributed across many settings.
From the posted details, the sponsoring agency is NIH, the activity category is Health, and the CFDA/Assistance Listing number is 93.866. The original closing date listed is 2023-09-27, and the opportunity was created on 2023-02-10. No award ceiling or expected number of awards is specified in the provided summary, so applicants would typically consult the full FOA text and NIH budget guidance for the most accurate funding expectations, allowable costs, and any institute-specific priorities tied to aging research.Apply for RFA AG 24 019
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Comparative Research on Determinants of Differences Among Human and Nonhuman Primate Species in Life Spans, Life Histories, and Other Aging-Related Outcomes, and Prospects for Translation (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2023-02-10.
- Applicants must submit their applications by 2023-09-27. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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